Importance of ICT in Education for Gifted Students

Gifted and talented children are those who are identified by professionally qualified persons who by virtue of outstanding abilities are capable of high performance. These are children who require differentiated educational programs and services beyond those that are normally provided by the regular school program in order to realize their contribution to self and society (Marland, 1972). A gifted child in the regular classroom may be the only child in the room; hence, he or she will not have the opportunity to learn with others of like ability. ICT can provide opportunities for students to develop and practice higher level thinking skills. The gifted students are spread around the world and ICT makes it possible that gifted students communicate with other gifted students all around the world. ICT can be used to acquire that type of knowledge which can satisfy the needs of the gifted children. So, the purpose of this paper is to determine the use of technology in education for the learning of gifted and talented students

Faithfully Negligent: Religious Implications for Criminal Negligence Cases

Do the actions of parents in withholding medical treatment from their children due to religious influence show wanton or reckless disregard for the safety and lives of their children? This project investigates the morally and legally complicated issue of the influence of religious beliefs in criminal negligence cases. My MRP is animated by the idea that similar cases in the past have been treated with leniency and ought to be given stricter punishments. I focus in particular on cases in which parents opt for alternative remedies or faith healing for ill children in ignorance or defiance of available medical treatments. I investigate the role of mistake of fact based on honest belief in prosecutions for criminal negligence causing death. Furthermore, I develop an argument that reliance on religious beliefs should not exculpate an accused parent from liability in criminal negligence cases. I argue that similar cases in the past have been treated with great leniency. This research proposes that cases of faith healing deaths be treated as cases of manslaughter, namely under section 222(5)(b), and that a minimum sentence of six years’ imprisonment be imposed for the death of vulnerable children

In vitro study of heat shock protein 60 expression and mitochondrial morphology in response to mitochondrial stress in HeLa cells

Diabetes mellitus ( DM) is a metabolic disorder and affecting worldwide as stated by WHO that diabetes will be seventh leading cause of death in 2030. Diabetes mellitus is characterized by hyperglycaemia and the production of reactive oxygen species that damages proteins, lipids and DNA. This further elicits mitochondrial specific stress, resulting in increased production of HSP60 which is a mitochondrial stress protein. The aim of this study was to investigate the mitochondrial morphology changes and heat shock protein responses of HeLa cells subjected to physiological levels of hyperglycaemia (25mM). HeLa cell growth was found to be slightly reduced with increasing glucose concentrations (10mM – 25mM ) as compared to the control (5mM). Furthermore, high glucose conditions (25mM) also affected mitochondrial activity as statistically significantly decreased mitochondrial dehydrogenase activity was observed as compared to the control. These results altogether conclude that high glucose (25mM) acted as a mitochondrial stressor. Mitochondria is a dynamic organelle that fuses and divides according to environmental stimuli and energy requirements. As a result the shape of mitochondria varies from small ovals to tubules and reticular networks. These events are mainly controlled by fission and fusion proteins and regulatory machinery. Therefore mitochondrial morphology was also analyzed by using confocal microscopy to determine the effects of high glucose (25mM) on mitochondrial morphology as compared to the control. It was found that the majority of mitochondria in the control (5mM) was tubular as compared to high glucose which showed increased mitochondrial fragmentation suggesting that growing cells in the presence of hyperglycemic conditions lead to mitochondrial stress. Mitochondrial specific stress results in selective induction of molecular chaperone, HSP60 which is mainly localized in the matrix of mitochondria. So furthermore , the expression of HSP60 was investigated. Consistent western blots results showed upregulation of HSP60 with heat shocked protein set as a positive control but not with high glucose concentration (25mM). Interestingly, HSP70 expression was found to be upregulated with high glucose (25mM) as compared to control therefore it can be concluded that there were more general cellular stress as compared to mitochondrial specific stress. This study concluded that high glucose (25mM) effects HeLa cell growth and mitochondrial activity as well as mitochondrial morphology . There are various evidence which links oxidative stress and mitochondrial dynamics and observed increased production of ROS along with short and fragmented mitochondria in high glucose conditions

INFORMED CONSENT STATUS IN OBSERVATIONAL STUDIES WITH RETROSPECTIVE DESIGN: A POOR SHOW

ABSTRACTObjective: Informed consent is very important to protect the rights of patients and is obtained as a vital component of any clinical study. Requirementof patient consent in retrospective research continues to stir controversy even today. Some of directions of regulatory authorities even waive off theconsent for retrospective studies, whereas few recommend that at least clearance from the Ethical Review Board may be taken or information topatient may be given or oral consent must be given by patient for usage of the data in any retrospective study. The aim of this study was to analyze thecurrent status of informed consent procedures in observational studies with retrospective design.Methods: This review was intended to find out the current status of procedures involved in informed consent in India and abroad. A total of 100retrospective studies were searched for this objective from the internet and other literature sources.Results: Data show that in 65% of studies neither informed consent/oral consent nor ethical clearance was taken. Only 1% of studies have beenconducted with informed consent as well as ethical clearance. Only 14% of studies were conducted with informed consent and 21% with ethicalapproval.Conclusion: The study reflects very poor status of informed consent in retrospective studies and noncompliance of ICH guidelines for clinical researchin relation to informed consent.Keywords: Clinical research, Informed consent, Retrospective studies

Nonfactorizable Contribution to B-Meson Decays to s-Wave Mesons

Two-body weak decays of bottom mesons into two pseudoscalar and pseudoscalar and vector mesons, are examined under isospin analysis to study nonfactorizable contribution

Malignant Gastric PEComa: A Rare Malignancy

Introduction: Perivascular epithelioid cell tumor (PEComa) is characterized by its perivascular location and spindle appearance of tumor cells with clear to lightly granular eosinophilic cytoplasm and a round-to-oval centrally located nucleus. Immunohistochemically, nearly all PEComas show reactivity for melanocytic (HMB-45 and/or melan-A) and smooth muscle (actin and/or desmin) markers. Malignant gastric PEComa is extremely rare and only 3 cases have been reported to best of our knowledge. We report a 4th case of malignant gastric PEComa.Case presentation: We are presenting a case of a 48 year-old Caucasian female who presented to the emergency department with complaint of abdominal pain for 3-4 weeks associated with intermittent nausea and vomiting. CT Abdomen/Pelvis with contrast showed a mass at the greater curvature of the distal stomach. Patient underwent resection of the mass and pathology result was consistent with malignant PEComa.Conclusion: PEComas are a family of rare mesenchymal tumors, composed of histologically and immunohistochemically distinctive perivascular epithelioid cells. These tumors co-express, the muscle and melanotic markers. Surgical resection is the best treatment option. Most commonly, they arise in the retroperitoneum and colon is most the common site followed by small intestine in the GI tract

Decreasing Mortality and Hospitalizations with Rising Costs Related to Gastric Cancer in the USA: An Epidemiological Perspective

BACKGROUND: There is no convincing data on the trends of hospitalizations, mortality, cost, and demographic variations associated with inpatient admissions for gastric cancer in the USA. The aim of this study was to use a national database of US hospitals to evaluate the trends associated with gastric cancer. METHODS: We analyzed the National Inpatient Sample (NIS) database for all patients in whom gastric cancer (ICD-9 code: 151.0, 151.1, 151.2, 151.3, 151.4, 151.5, 151.6, 151.8, 151.9) was the principal discharge diagnosis during the period, 2003-2014. The NIS is the largest publicly available all-payer inpatient care database in the US. It contains data from approximately eight million hospital stays each year. The statistical significance of the difference in the number of hospital discharges, length of stay, and hospital costs over the study period was determined by regression analysis. RESULTS: In 2003, there were 23,921 admissions with a principal discharge diagnosis of gastric cancer as compared to 21,540 in 2014 (P \u3c 0.01). The mean length of stay for gastric cancer decreased by 17% between 2003 and 2014 from 10.9 days to 8.95 days (P \u3c 0.01). However, during this period, the mean hospital charges increased significantly by 21% from $75,341 per patient in 2003 to$ 91,385 per patient in 2014 (P \u3c 0.001). There was a more significant reduction in mortality over a period of 11 years from 2428 (10.15%) in 2003 to 1345 (6.24%) in 2014 (P \u3c 0.01). The aggregate charges (i.e., national bill ) for gastric cancer increased significantly from 1.79 bn $to 1. 96 bn$ (P \u3c 0.001), despite decrease in hospitalization (inflation adjusted). CONCLUSION: Although the number of inpatient admissions for gastric cancer have decreased over the past decade, the healthcare burden and cost related to it has increased significantly. Inpatient mortality is decreasing which is consistent with overall decrease in gastric cancer-related deaths. Cost increase associated with gastric cancer contributed significantly to the national healthcare bill

The Role of MgO Modifier on Physical, Structural, Optical andThermoluminescence Properties of Lithium Borate Glass System

Synthesis of lithium borate glass system was carried using the melt quenching technique with varying concentrations ofmagnesium followed by analysing the different characteristics such as physical, structural, optical and thermoluminesceneusing various techniques eg. X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), UV-Visspectroscopy, and Thermoluminescence (TL). The obtained XRD pattern confirmed the amorphous nature of the preparedsamples. Relevant physical parameters have been evaluated to study the response of these properties with respect tomagnesium content. The density and molar volume values showed that the network structure changed with increasingmagnesium content. It is evident from the FTIR spectra that the network of the prepared samples predominantly containsBO3 and BO4 units. The UV-vis spectra confirmed a decrease in the direct and indirect band gap values with increase inMgO content. Optical parameters namely refractive index, electronic polarizability, reflection loss and dielectric constantwere also calculated and found to be in good correlation with other studies. Following gamma rays irradiation with differentdoses, TL glow curves of prepared glasses were analysed. Deconvolution of TL glow curves was done using glow curveconvolution deconvolution (GCCD) function and trapping parameters of isolated peaks viz. activation energy and frequencyfactor have been determined